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Hormetic stresses include two groups of agents that (a) slow down aging by inhibiting the TOR pathway and (b) increase aging tolerance, without affecting the aging process.
On normal diet, mutations of the C. elegans homolog of RICTOR, an mTORC2 component, have been shown to increase body fat, slow development, reduce body size, and increase aging rate.
The second way is to increase aging tolerance, which allows an organism to survive catastrophes caused by age-related diseases.
Most medical treatments increase aging tolerance, thus extending an average life span despite chronic age-related diseases.
As a matter of fact, almost all medical interventions (including by-pass surgery and teeth proteases) increase aging tolerance rather than slow down aging.
To extend lifespan, they either should inhibit the TOR pathway or increase aging tolerance.
Similar(53)
That decreasing effect increases with increasing aging years.
Thus, anatomical modifications of a myocardial blood supply would increase aging-tolerance without affecting aging itself.
Another way is to increase aging-tolerance, despite the same rate of aging.
Physical activity can also increase aging-tolerance, acting as hormesis B. The TOR pathway stimulates Cap-dependent protein synthesis.
AGE intake can also increase AGE-accumulation.
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