Sentence examples for increase affinity to from inspiring English sources

AuNP aptamer conjugates can increase affinity to target analytes through multiple ligand receptor interactions, increased surface roughness, and ligand density.

In other RNA-binding proteins RGG motifs act as ancillary motifs, which increase affinity to RNA or confer sequence specificity for RNA binding (Burd and Dreyfuss, 1994; Darnell et al., 2001; Lamm et al., 1996).

We then investigated whether an increase in the number of RBFOX1/2 motifs was associated with increased affinity to RBFOX1/2 RRM.

However, the chimeric dscuPA33khC bound the activated platelet and significantly increased affinity to platelet clots as compared to fibrin clots.

We designed and synthesized a Sulindac analog K-80003, which has increased affinity to RXRα but lacks COX inhibitory activity.

Binding assays indicated that the Ii-Key/HPV16 hybrid has increased affinity to HLA-DR4+ cells relative to the epitope-only peptide, which may explain its increased potency.

Molecular modeling of these alkaloids docked to a homology model of Pgp was employed to optimize ligand protein interactions and design analogues with increased affinity to Pgp.

The results showed not only that the rhBMP2 CBD had an increased affinity to collagen, but also that this binding was very stable during a prolonged period of time.

In the present study, we report that a sustained depolarization slowly inactivated (half-time = 10 15 min) ROMK channels that had been engineered for increased affinity to internal polyamines.

In conclusion, both the soluble receptor-based and cell-based binding assays can be used to identify IgG1 variants with increased affinity to FcγRIIIa and unaltered affinity to FcγRI and FcRn.

We then experimentally test the approach by designing extensions for p53 and dystroglycan-based peptides predicted to bind with increased affinity to the Mdm2 oncoprotein and to dystrophin, respectively.