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In this study, we demonstrate that our method is able to measure tumor volume changes despite resection cavity collapse, while traditional 1D and 2D techniques are incorrectly influenced by the overall resection cavity configuration.
In this analysis, we tested whether conclusions from relatively small studies (less than 200) incorrectly influenced conclusions drawn from larger studies with more statistical power studying the same determinant, or that results from studies with a relatively short followup (cutoff 24 months) altered conclusions from studies with a longer followup.
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It is well known that such outliers may disturb the model and incorrectly influence the results [ 25], thus in the next steps of statistical analysis the data for these samples were excluded.
Unreported costs and risks, emphasized benefits, undisclosed financial conflicts of interest and exaggerated claims about new medical approaches may create medicalization of non-diseases or incorrectly influence decisions about treatment choices and medical care [30].
Finally, other variables may have existed (unknown or incorrectly omitted) which powerfully influenced outcome but which were not included in the models.
The view of Cartwright et al (2001) and of COMARE in its Fourth Report (1996) that the absence of a case of CL in Seascale during the war provides evidence against the PM hypothesis was evidently influenced by their incorrectly attributing details of the extensive post-war housing construction in Seascale to the war years.
We note that the cases with terminations in the misclassification group in our study had all multiple anomalies and that the incorrectly diagnosed malformations would not have influenced medical decision.
It is possible that a patient who discontinued a study medication did so based on physician instructions, and this would have been incorrectly classified as non-persistence and may have influenced study results.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com