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DOI: http://dx.doi.org/10.7554/eLife.03737.004 As D. melanogaster females often retain eggs post-fertilization, leading to unacceptable levels of contaminating older embryos in embryo pools (Harrison et al., 2011), we manually removed embryos of incorrect stages by inspection under a light microscope, as previously described (Harrison et al., 2011).
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It originally included an incorrect stage time for Kurupt FM's DJ set.
Our discovery of cell cycle specific changes in c-Myb activity raise the possibility that oncogenic versions of c-Myb may transform cells by regulating some target genes in the incorrect stage of the cell cycle, which could stimulate cell cycle progression or inactivate cell cycle checkpoints.
However, these tumors generally have a much better prognosis, and incorrect staging may lead to potentially unnecessary treatment.
Incorrect staging of NSCLC can result in unnecessary thoracotomies and early local or distant relapse after surgery [ 2, 3].
This cannot be explained by stage migration alone, as any artefact brought about by incorrect staging is eliminated when all stages are considered together.
The underlying accuracy represents the number of patients who would benefit most from adjuvant chemotherapy but may miss out on it due to incorrect staging.
The cost of staging 98 patients using MRI (including the resource implications from incorrect staging) then amounts to £68008 – a resource difference of £56768 compared with EUS and £31688 compared with DRE.
If only procedure costs were included and the resource implications resulting from incorrect staging ignored, the total cost for EUS would be £7644 and for MRI the cost would be £13 524, a difference of £5880.
Treatment outcome is also influenced negatively, because older patients often receive a delayed diagnosis or incorrect staging, possibly due to a reluctance to treat aggressively because of patients' co-morbidities or disabilities (Chang et al, 2003; Testori et al, 2009).
Thus, in order for the total cost for MRI to equate with EUS (taking into account the resource implications of incorrect staging), the cost of an MRI procedure would need to be substantially higher, that is, £1079.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com