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The incorrect processing of proIAPP to produce partially processed forms of the peptide has been proposed to play a role in the initiation of islet amyloid in vivo by promoting interactions with proteoglycans of the extracellular matrix.
The company said in a statement that the accounting for the first three fiscal quarters "could not be relied upon," due to incorrect processing of certain transactions.
Using this approach we expected to avoid problems in the expression, folding or targeting of the polypeptides due to incorrect processing.
Moreover, targeted cleavage of the H1 RNA moiety in whole HeLa extracts by RNase H and an antisense deoxyoligonucleotide H1-1, whish is directed against the specificity domain of H1 RNA (Figure 4B), caused incorrect processing of the 5' leader sequence of precursor tRNATyr by RNase P (Figure 4C, lane 3 versus 2; arrow head) and abolished transcription of the mini-rDNA gene (Figures 4D and 4E).
26, 58, 64 Furthermore, some of these genes are involved in proteosome or autophagic process (parkin, LRRK2, DJ1), thus suggesting that they could be involved in the incorrect processing of misfolded or aggregated alpha-synuclein.
The fact that both the full-length and the processed Creb3l2 mutants display a similar loss of activity compared with the corresponding wild-type proteins strongly suggests that the primary molecular defect in feelgood leads to loss of transcriptional activity, or nuclear transport rates, rather than incorrect processing by S1P or inefficient transport of Creb3l2 from ER to Golgi.
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The plant-based expression of native NaV capsid protein was poor due to incorrect mRNA processing, but a plant optimized gene enhanced expression [ 22].
O2PLS identified unique variables in individual compositions that were potentially incorrect measurements, or processing defects, which in turn can be used to aid quality control or processing optimisation with regards to DOE.
However, the physiological effects of different cultivation strategies are often difficult to separate from the molecular effects of the gene construct (e.g., cellular stress through over-expression or incorrect post-translational processing).
result in a recent paper Huang, Wang, Wang, Gao, and Wang (2010) (Computers & Industrial Engineering 58 (2010 58 633) is incorrect because job processing times are variable due to both deteriorating jobs and learning effects, which is not taken into account by the authors.
No or low activity of other proteases may be explained by incorrect folding or processing.
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