We decided to use these variables that implicitly take into account the 3D structure of the antibody, rather than the modeled structure itself to avoid biases arising from incorrect modeling of some parts of the molecule, especially the H3 loop.
Their incorrect model also used in [9].
Incorrect background model updating tends to introduce incorrect models because of motion ambiguities.
Fig. 14 Difference of DIC between correct and incorrect models.
Despite the incorrect model assumptions, the ratio estimator was approximately design-unbiased, and the confidence intervals were valid.
The performances of these methods under correct and incorrect models specifications are evaluated in a simulation study.
It was shown that increasing the sampling time above a given threshold resulted in identifying an incorrect model.
In Fig. 14 we compare the deviance information criterion (DIC) between the correct and the incorrect model.
While even science manages to make correct predictions with wildly incorrect models, at least the lucky speculator can spend his ill-gotten gains.
It is this feature that eliminates the incorrect model for that scenario; for details, see Baker 1989 and Shanahan 1997, Chapter 6.
