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These mutations result in either a complete lack or reduction of protein or an incorrect functioning protein at the apical surface of epithelial cells [48].
In some cases, incorrect functioning of cytokines (frequently caused by underexpression or overexpression of certain cytokine genes) directly favors development of cancer.
The ratio of the length of the articular route to opening gap of dental arches may be a significant indicator, characterising the degree of dysfunction intensification enabling initial diagnosis of the source of the human mastication organ incorrect functioning.
In the case of persons with mastication organ incorrect functioning, relation of articular route to the maximum opening gap of dental arches reached accordingly the level of 44 ± 11% in the case of disorders caused by improper muscles operation and 35 ± 11% in people with dysfunction caused by temporomandibular joints operation.
The evidence for the possible involvement of the 450G (m.1097G) in the incorrect functioning of bridge mt-B2c appears quite likely, since the disruption of the G809 C770 base pair by mutagenesis has been shown to be detrimental to ribosomal function (34, 35).
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Approximately 50% of the entries have uncertain, unknown, or incorrect function annotations because these are made by automated methods based on sequence homology.
The latter include impairment of cell division control systems, immunological control systems, and incorrect function of antioxidation mechanisms.
For example, transferring annotations based on similarity works sometimes, but could easily associate a paralog with an incorrect function.
As a result, it is known that many databases contain incorrect function assignments, and these erroneous assignments propagate from one database to another.
T at −1 and A at +1 positions not only alter DNA bendability but also put incorrect function groups for RelA to interact.
In addition, if a protein is assigned an incorrect function in a database, the error could carry over to other proteins for which functions are inferred by sequence relationship to the protein with errant function assignment [ 12- 14].
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