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These domains are widely used in sequence analysis where incorrect boundaries imply erroneous delineation of conserved regions.
These ORFs may have novel domain structure, but more likely, they are just partially correct sequences with errors such as frame shift and incorrect boundaries and should be excluded in further analysis.
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It has been found that the error due to incorrect boundary conditions diminishes over a couple of times of the distance of fibre spacing (centre-to-centre).
These variations imitate specific uncertainties or incorrect boundary conditions and are each elucidated in separate sections of the manuscript.
Accurate boundary annotation has been largely overlooked in pair-wise sequence comparison, because incorrect alignment boundaries rarely detract from the identification of homologous proteins.
Projection methods, that split the computation of the velocity from the pressure, are very popular in fluid dynamics since the boundary errors generated by the projection method are localized mainly near the boundary layers where the incorrect pressure boundary conditions are imposed.
Without repeat masking, GENESCAN actually predicted 52 loci based on the original 636,503-bp sequence, but the predicted results indicated that 23 of these were derived from repeats, and 5 non-repeat genes had incorrect exon boundaries that were mixed with intron or repeat sequences.
Artefacts in sinusoid or bile canaliculi segmentation may lead to incorrect cell boundaries.
To understand how often incorrect alignment boundaries occur, searches were performed with both BLASTP and SSEARCH, using BLOSUM62 (BL62) with the RPD2 query set and library.
However, unlike fungal effector prediction pipelines that strictly select effector candidates based on a predicted signal peptide, our clustering approach can to some extent compensate for incorrect gene boundaries.
Indeed, an area preserving algorithm is used to compensate the problem of incorrect iris boundary detection in presence of noise.
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