Limited advances have been made in chemotherapy, including the design of the triplet regimen and the incorporation of dose intensification (dose-dense) formulations.
An additional difference in dosing strategies, unique to the edoxaban trial, was the incorporation of predetermined dose reductions in response to the presence of certain characteristics that could lead to increased drug exposure [ 19].
IGF-I promoted otic proliferation when compared with control cultures (Figure 3 B, compare b and e), while Sorafenib impaired BrdU incorporation in a dose dependent manner.
As demonstrated in Fig. 5, SFN inhibited [H]-leucine incorporation in a dose-dependent manner.
Consistent with previous studies in ER+ cells [ 18, 68, 69], I3C significantly reduced H-thymidine incorporation at all doses tested.
Stimulated lymphocytes of both species were exposed to functional tests (proliferation, metabolic activity, radioactive precursor incorporation) under increasing doses of methylmercury (0.1 to 10 μM).
As shown in Figs 4C and S4B, α-asarone and β-asarone treatment increased EdU incorporation in a dose-dependent manner.
In contrast, CNP increased SO4 incorporation in a dose-dependent manner with maximal stimulation at 100 and 1000 n M (P < 0.001; Figure 2d).
Examples cited to support the incorporation of low-dose beneficial effects into exposure standards ignore other adverse effects that are induced by different mechanisms and that occur at similar or lower dose levels.
Nonetheless, this finding adds to the growing body of nonrandomised data suggesting that incorporation of high-dose IV MTX±cytarabine into treatment protocols may lower the risk of CNS relapse in patients with DLBCL at high risk of the complication.
For example, the knockdown of L1 expression by L1 ORF2-specific antisense oligonucleotides drastically inhibited H-thymidine incorporation in a dose-dependent manner in human transformed hepatoma (Hep3B) cells [ 28].
