Recently there has been renewed interest in developing second and third generation vectors improved in the control of transgene expression by incorporating tissue-specific promoters.
Shlomi et al., for instance, proposed a method to take into account tissue specificity in metabolic models by incorporating tissue-specific gene expression states into the flux optimisation scheme [ 11].
Effectively incorporating patient-derived tissue into drug screens is challenging due, in part, to constraints on obtaining viable surgical specimens and difficulties expanding primary cancer cells to quantities necessary for large-scale screening.
Incorporating additional indicators of tissue perfusion into our bedside assessments may help to improve the identification of the hypoperfused patient.
"The bus is going to places, incorporating music, incorporating art".
The PBPK model developed herein refines the assessment of past tissue exposure by incorporating physiologic processes that greatly affect POP kinetics.
Similar approaches usually comparing tumour and normal tissue and sometimes incorporating cDNA subtraction have been used to examine progression in lung cancer [ 83], rhabdomyosarcoma [ 84, 85], ovarian cancer [ 86], kidney cancer [ 87], melanoma [ 88], prostate cancer [ 78], Ewing's sarcoma [ 89] and colon cancer [ 33].
Incorporating advances in stem-cell-biology and tissue engineering may allow the generation of patient-specific humanized mice.
This data article presents data associated with the research article entitled "Evaluation of cell-laden polyelectrolyte hydrogels incorporating poly L-lysine) for apoly L-lysinen cartilage tissue engineering" (Lam et al., 2016) [1].
They may allow a combinatorial approach with a mix of materials while incorporating multiple processing techniques for successful creation of tissue-specific ECM mimics.
Incorporating normal cis-regulatory domains in the vector confers tissue specific gene expression.
