Sentence examples for incorporating negative feedback from inspiring English sources

Surprisingly, an ERK cascade signaling model incorporating negative feedback and a graded, analog single cell dose response is shown to be consistent with the observed population responses.

By incorporating negative feedback control, nanoSTATs further expand the repertoire of nanomedicines available for the treatment of thrombosis and may lead to the development of safer antithrombotics.

A further limitation of the Boolean formalism, particularly when focusing on logical steady state analysis with no distinction between processes of different time scales, is the difficulty of incorporating negative feedback loops.

This example illustrates the difficulties in incorporating negative feedback loops in a binary Boolean model.

The latter stipulation ensures that fate control also incorporates negative feedback on renewal, which is why it still achieves the desirable stability and robustness properties of renewal control, even while escaping the latter's limitations.

DOI: http://dx.doi.org/10.7554/eLife.11611.022 In computational models that incorporate negative feedback as well as positive feedback, simulations indicate that although competition can proceed in much the same way as discussed above, it is possible to specify parameter values in such a way that the two-peak steady state becomes stable (Howell et al., 2012).

We have studied EGF-induced signal transduction to ERK in single HEK293 cells, finding that the conversion of an analog signal at the single cell level to an apparent digital response at the population level can be mediated by a combination of cell-to-cell variability in protein expression and a pathway design that incorporates negative feedback.

Such mechanisms often incorporate negative feedbacks allowing adjustment of transcription level to match the environmental fluctuations or tissue-specific developmental needs; these feedbacks may as well provide compensation for a loss-of-function mutation in one of the alleles.

Moreover, incorporating more negative feedback loops always tend to enhance system stability.

The model incorporates multiple negative feedback loops through which the PI3K/AKT pathway leads to the negative regulation of RTK signaling.

Motivated by the discovery of oscillations in tumour necrosis factor-alpha (TNF-alpha) concentration in the aqueous humour of rabbits undergoing corneal allograft rejection, a simple mathematical model is developed for the regulation of TNF-alpha, which incorporates both negative feedback and amplification pathways.