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To determine whether any conventional clinical prognostic factors for metastasis from uveal melanoma retain prognostic significance in multivariate models incorporating gene expression profile (GEP) class of the tumor cells.
Several studies address this problem by incorporating gene expression information to filter the active interactions.
The method of incorporating gene expression values is based on E-Flux reported in the literature [ 46].
We chose to leave Pathway Distiller unbiased for any one experiment by not incorporating gene expression information.
FBA can be integratively analyzed with genome-wide data by incorporating gene expression measurements into metabolic modeling.
We suggest that these intrinsic differences between the data sets should be considered in the design and analysis of future studies incorporating gene expression data.
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This matrix equation incorporates gene expression signatures representing cell types (e.g. white blood cells) so it may be solved using standard linear least-squares fitting for X, which is the relative amounts of those cells in the mixture of interest B (e.g. a white blood cell sample).
We intend to incorporate gene expression data on other abiotic stresses as well.
Currently, Metscape 2 can incorporate gene expression and metabolomics data across different time points or different experimental conditions.
The tool is specially suited for exploring the metabolic repertoire of sequenced genomes but does not incorporates gene expression measurements.
Our ultimate selection strategy also incorporated gene expression data, an RNAi screen, and a network analysis to focus the list on the most likely driver genes within CNAs.
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