In particular, we highlight MAS-ML, an MAS modelling language that performs a conservative extension of UML while incorporating agent-related concepts to represent proactive agents.
These include novel combinations incorporating agents such as irinotecan, topotecan, gemcitabine, vinorelbine and anthracyclines into docetaxel-containing regimens.
This may be due in part to the fact that breast cancer is an extremely complex and heterogeneous disease that operates multiple mechanisms of chemotherapeutic response and resistance which are not consistent across different subtypes, particularly in the case of combination regimens incorporating agents that act by multiple mechanisms.
Our research leverages a Conditional Value-at-Risk (CVaR) perspective to managing risks that can incorporate agent based simulation data in the decision-making process.
Once validated, a natural extension is to specifically incorporate agent memory and learning following Quek et al. (2009) and multi-player PD from evolutionary game theory to map the complex transaction networks that emerge over time.
In addition to the need for local delivery, a critical barrier to progress in the field is the need to incorporate agents effective against biofilm.
Future work with this method could easily incorporate agents that modify the phenotype of NK cells that could favor homing and enhance multiple facets of effector functions [ 90– 92].
In particular, several agent-oriented methodologies, incorporating suitable agent models, frameworks and tools, have been to date defined to support the development lifecycle of distributed agent systems (DAS).
But incorporating an agent that pulverizes microbes is an idea ripe for grime-fearing techies — a sanitizer for the optimized lifestyle.
Several distributed management architectures, incorporating mobile agent (MA) technology, have been recently proposed to answer the scalability limitations of centralised models and the flexibility problems of static hierarchical frameworks.
Lenalidomide favours a uniform TNF- α and IL-8 inflammatory and IGF-1 secretory profile of myeloma cells, an observation that raises important questions for therapeutic approaches incorporating the agent.
