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In this work, we have presented two methods for incorporating additional knowledge to constrain GRN inference by adding priors on the network structure.
To this end, we first provide an analysis of the currently used connectivity maps and integrate these into a map incorporating additional knowledge from functional connectivity studies.
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In addition, we present a symmetric matrix co-factorization (SMCF) method to incorporate additional knowledge pertaining to chemical properties in estimating the substitution tendencies among ions with extremely small amount of previous knowledge in the database.
In [25], it is stated that the main difficulty is that audio source separation problems are usually mathematically ill-posed and to succeed it is necessary to incorporate additional knowledge about the mixing process and/or the source signals.
In such cases, in order to achieve separation (convergence to a true minimum), it is necessary to incorporate additional knowledge about the mixing process and/or the source signals; however, this would make the separation process semi-blind or supervised.
A hypothetical model was developed in the first instance by incorporating additional variables (knowledge and personal norm) into the classic theory of planned behavior (TPB) model.
The first incorporates additional biological knowledge, such as reaction thermodynamics [ 9] or multioptimization [ 10].
All of these refinements may also be used to incorporate additional prior knowledge.
In this section, we extend our model to incorporate additional prior knowledge such as SNP locations and biological pathways.
It is possible to incorporate additional expert knowledge in the scoring model by assigning a relative weight to the S score of an individual descriptor.
However, this approach yields models that cannot incorporate additional mechanistic knowledge (e.g. reaction parameters) in contrast to our approach, where we aimed at constructing a biologically realistic model by utilising all available kinetic information.
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