Therefore, the system was expanded to incorporate quality control tools to remind personnel to read samples on a regular basis, flag duplicate or missing results, and report contamination rates.
The laboratory is certified according to the Clinical Laboratories Improvement Act, and procedures incorporate quality control (QC) measures to ensure accuracy and precision of results, including annual proficiency testing compliance (Norrgran et al. 2006).
To account for the likelihood of errors, subsequent analyses have been designed to incorporate quality control filters in their respective bioinformatics pipelines, as well as a larger extent of transcriptome sampling via sequencing depth.
Data from each electronic source within and across participating sites were merged and cleaned at the data coordinating site in preparation for analyses, using SAS statistical software.[ 10] We used a completely automated triple abstraction process to incorporate quality controls to reduce inter- and intra-site variability and to improve accuracy of data collection.
As a further check, the Sphygmocor® software incorporates a quality control feature which is displayed on the screen.
Alternatively, it is possible to reduce the sequencing error by incorporating adequate quality control measures such that even low frequency alleles could be reliably detected and quantified [23], [24].
Repeat samples and blanks were incorporated for quality control purposes, and results analyzed using SDS software (version 2.2).
However, if associations are to be accurate and meaningful, this urgently requires assays that have a reproducible, sensitive and specific performance in such material, incorporating improved quality control as has been achieved for ERα and HER2 assays [ 71- 73].
Globally many regulatory authorities incorporate quality management system as one of the mandatory requirements for the regulatory control of high-risk medical devices.
