However, no existing method incorporates pathway-level information into the assessment of the consequences of a mutation.
Until recently, few computational approaches were available for incorporating pathway knowledge to interpret high-throughput datasets.
For example, incorporating pathway information, evolutional knowledge, and reducing the noisy in the individual networks before the integration.
The superior performance of capDSD in this context confirms that treating the pathways as probabilistic units is more powerful than simply incorporating pathway edges independently into the network.
Network-based identification methods aim to incorporate pathway or gene network information (typically generated from expression datasets) information to help identify functional modules, or improve the prediction.
Incorporating confidence and pathways into our diffusion-based distance metric DSD, we studied whether it was best to incorporate pathway information as edges or as controlled-access highways in an augmented graph.
So it remains to answer the main question of the article, whether using the augmented pathways as controlled-access highways is a better way to incorporate pathway information than just using individual edges.
Caleydo StratomeX solves this problem by incorporating pathway diagrams displaying functional relationships between the genes, and CircleMap plots can also be used as nodes to construct a network diagram for this purpose.
I'm a microbial physiologist, so I'd love to know more about the company's plan to incorporate pathway-engineering methods into drug development.
Evolution may have built upon this simple reflex circuit, incorporating pathways from the MB that generate learned behaviors in response to a CS.
