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The four-stage engineering incorporates generalizable design principles and improves the pairing efficiency of noncognate glutamate with tRNAGln by over 10-fold compared to the wild-type enzyme.
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Clinicians who care for patients with these common conditions should be alert to the possibility that a proactive approach incorporating generalizable principles of disease management may either attenuate this loss of function or help the patient and family anticipate future needs.
In this paper, we describe the process used to develop BreastHealthDecisions.org, the results of the usability testing, and how stakeholder input was incorporated into the generalizable web-based tool.
GOMER (generalizable occupancy model of expression regulation) calculates binding probabilities on the basis of position weight matrices, and incorporates the effects of cooperativity and competition by explicit calculation of coupled binding equilibria.
It incorporates 1950s influences.
To develop a generalizable framework that can incorporate expert knowledge into data-driven processes in a semiautomated way while providing a metric for optimization in a biomarker selection scheme.
Despite context-specific results – depending on the levels and distribution of HIV burden in the country (South Africa here), and the definition of equity (geographical equity here) – this paper presents a generalizable, intuitive way to incorporate an equity metric into resource allocation for health interventions, while allowing for a calculation of how such incorporation affects efficiency.
Such results, however, might not be generalizable to developing countries that incorporate different ethnicity, religions, cultures, economic, and political backgrounds.
These results show that all four topological measures provide highly significant (p-value < 1e-16) enrinhment in pathogen targets, with betweenness and clustering coefficient displaying highest enrichment, thereby demonstrating the added value of incorporating PPI data into inferred networks for a generalizable approach to identify target regulatory nodes within networks.
The results are generalizable and the study was able to incorporate appropriate adjustments for demographic characteristics, such as age, sex, and race/ethnicity, as well as clinical characteristics, such as number of comorbidities.
It is therefore important to resist extrapolating these findings to generalizable distinctions between the countries or the study sites incorporated in this work.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com