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In fact, TLS can be further divided into two sub-branches: the "error-free TLS", taking place when Pol- η incorporates the right nucleotide opposite a CPD, and the "error-prone TLS", occurring when Pol- η incorporates a wrong nucleotide opposite a 6-4 PP and then stalls.
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Pol η is unique in its ability to promote proficient and error-free bypass of UV-induced cyclobutane pyrimidine dimers, although it incorporates wrong nucleotides at a high rate opposite several other lesions.
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