A recent reanalysis of the PRAVO study toxicity data incorporated details of radiation doses (6 30 Gy) delivered to the small bowel, from treatment-planning CT scans (Bratland et al, 2011), and the authors concluded that the previously reported DLT data might have reflected an adverse radiation dose-volume effect rather than a toxic effect of vorinostat itself.
Growth factors incorporated nanoparticles did not show any toxicity against fibroblasts up to 4 mg/ml culture medium.
Intracellular iron released from transferrin is rapidly incorporated into ferritin, minimizing its inherent toxicity [ 17, 30, 31].
Early death due to PD before evaluation, toxic death due to chemotherapy or early chemotherapy discontinuation because of toxicity were considered as treatment failures and incorporated in the evaluable patients.
In the US model, hospitalizations were not included directly in the analysis as these were incorporated as part of the cost of toxicities.
Using RMCE, we successfully incorporated several transgenes useful for lineage identification, cell toxicity studies, and gene overexpression to study the hepatocyte lineage.
We obtained self-reported assessments of toxicity from all 10 patients who incorporated fasting with their chemotherapy treatments.
In PAR-CLIP, 4-SU and 6-SG are added to the growth medium, which are then taken up by cells and eventually incorporated into newly-synthesized RNA molecules without obvious toxicity.
Hernández-Ortiz et al. [ 12] examine genotoxic effect of opal nanoparticles on 3T3 cells which shows less toxicity to DNA and the percentage of incorporated BrdU in 3T3 cells indicated a minor DNA damage of the cells; they further showed that opal nanoparticles did not cause repairable DNA damage to the cells indicating cytocompatibility of opal nanoparticles [ 12].
However, it is challenging for the current system to provide a real-time high-resolution image because the incorporated MnCl2 solution through microinjection usually results in image blurring or toxicity due to the uncontrollable diffusion of Mn2+.
