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In the Sanger method, which became the more commonly employed of the two approaches, DNA chains were synthesized on a template strand, but chain growth was stopped when one of four possible dideoxy nucleotides, which lack a 3' hydroxyl group, became incorporated, thereby preventing the addition of another nucleotide.
In the most commonly used method, the Sanger method, DNA chains are synthesized on a template strand, but chain growth is stopped when one of four possible dideoxy nucleotides, which lack a 3′ hydroxyl group, is incorporated, thereby preventing the addition of another nucleotide.
In addition, seasonal variation can also be incorporated, thereby accounting for variability in travel schedules and activities, and of course the seasonal prevalence of particular diseases (e.g., influenza).
In the third set of simulations, an acceleration in the C to T substitution rate was incorporated, thereby modeling an increase in their mutation rate due to the deamination of methylated C's in CpG pairs [ 14].
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In this way, excipients could be altering the overall ADMET properties of an incorporated drug thereby affecting its intended therapeutic efficacy and/or enhancing adverse side effects.
Systematic investigation of live cells cultured for different durations in scaffolds of different compositions (9 1 and 8 2 PVA Gelatin with and without galactose) reveals significant improvement in cell cell communication and proliferation on galactose incorporated scaffolds, thereby demonstrating the positive influence of ASGPR-mediated adhesion.
Ara-GTP is subsequently incorporated into DNA, thereby inhibiting DNA synthesis.
Although bacterial and vegetable cellulose are identical from a chemical point of view, their distinct microstructures seem to influence the chemical stability of incorporated copper nanostructures, thereby with potential effects on the antibacterial properties of the corresponding composites.
For the first approach, a direct or paired analysis calibration incorporated eight articulated specimens, thereby allowing for the application of AAR and radiocarbon analysis of the same specimen and effectively eliminating both intrashell variability and time averaging as factors in the calibration.
Indeed, several previous reports have indicated that, even though a low level of A3G was detected in Vif+ HIV producing cells, Vif may act as an effective barrier to prevent A3G from being incorporated virions virus and thereby completely neutralize the antiviral activity of A3G [22] [24] [26]]–[24] [26]
The amount of the incorporated trace elements is thereby dependent on the serum levels present.
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