If monitoring of contacts is added to the intervention (incorporated in the model by assuming that w = 15), the effective reproduction number can be further reduced to 0.53.
For example, if direct costs for asymmetry are incorporated in the model, we find that a new (local) fitness optimum with symmetric damage distribution emerges (Supplementary material).
Edge effects are incorporated in the model through a shape function that modulates the hydrodynamic loading as a function of the distance from the edges.
Nonetheless, the relative dose intensity was also incorporated in the model, allowing for the fact that some patients may not take the planned dose for the whole treatment period until progression or death.
The fractions determined by Levitt (16) provided the initial estimates that were incorporated in the model for validation.
Inherent to mathematical modelling, assumptions must be made about the underlying processes that are incorporated in the model.
Most of these genes (77% and 78%) were not influenced by DNA polymorphisms (which were the cause of variation in 2,330 genes) or genotype (affecting 773 or 1,336 genes, depending on the genetic group or isolation site that was incorporated in the model).
Finally, left and right censoring are incorporated in the model to account for the experimental limitations that preclude exact measurements of extremely high and extremely low intensities.
Whereas the importance of each factor in decision making may differ between facilities and nations, we believe that our model in general is likely to be widely applicable as many of the factors that we incorporated in the model have been reported in a variety of settings and countries.
There are additional issues relevant to the management of women at high-risk for breast cancer that were not incorporated in the model, and may influence the cost-effectiveness of screening with MRI.
In addition to the central variables of drug use and crime, we have incorporated a number of covariates in the model that are frequently associated with drug use and crime.
