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Some of the 39 E. coli and 24 Clostridium genomes incorporated in our study are not human gut bacteria and were used here to improve the reliability of our model.
Tetramethylammonium (TMA+), tetraethylammonium (TEA+), tetrapropylammonium (TPA+) and tetrabutylammonium (TBA+) ions have been incorporated in our study for the systematic control of ionic interactions within PFSIs according to the chain-length of ammonium ions.
Only funds allocated to HAT control were incorporated in our study; we excluded funds earmarked for research.
Ligand and non-ligand activated transcription factors involved in the coordinated regulation of drug-metabolizing enzymes and transporters were incorporated in our study.
In order to have a broader overview of the endoglucanase evolution in the infra-order Tylenchomorpha, the gene structure of six additional genes was incorporated in our study.
An additional important factor for realistic scenarios which was also incorporated in our study is the prior training of tutors, who help students round off the role-play scenarios in their imagination [ 44, 45].
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Having not incorporated mortality in our study should be considered as a model limitation.
The levels of incorporated DHA achieved in our study are similar to previous reports in both murine [30], [31], guinea pig [12] and human cells [41], which reported DHA levels exceeding 10 mol% in vivo following fish oil feeding.
The way we incorporated the reproducibility in our study was to consider only signals as relevant that reached a certain threshold in both replicates, as was the case in the analysis by Wade and colleagues.
In our study, we incorporated these considerations and analyzed our data using a multilevel linear model with mixed effects [ 19- 22].
In our study, we incorporated core OMERACT symptom domains, which allowed for clustering based on a comprehensive symptom profile.
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