We therefore designed three CD19-specifc CARs that lacked the IgG1 Fc region, and we incorporated combinations of CD28 or 4-1BB trandmembrane and co-stimulatory domains.
The research methodology for this study incorporated a combination of analytical, observational and empirical engineering methods.
Key definitions of biomarkers and how they should be developed, validated, and incorporated in combination clinical trials are outlined.
I tested a new capturing methodology to assess the small mammal diversity of an old-growth forest in Patagonia, based on a randomized and balanced design, which incorporated a combination of different trap types, bait types, and placement heights.
Therefore, anti-angiogenic drug regimens are at present increasingly incorporated into combination therapies for GBM [ 2].
Among them, the taxanes (paclitaxel and docetaxel) have raised great enthusiasm, and have been rapidly incorporated in combination regimens (Dombernowsky et al, 1996; Moliterni et al, 1997).
The TOT model incorporated a combination of competency-based and mastery learning methods applied through a defined "trainer pathway," in which a provider is ultimately able not only to train peers, but also to design and develop curricula for training programs.
Radiation heat transfer is incorporated via a combination of ray tracing, Monte Carlo, and finite volume techniques.
According to his signature style, however, they are best incorporated into unexpected combinations, as in a necklace of 26 turquoise boulders peppered with emerald pavé.
The nonlinear models for bridge columns and isolation devices are incorporated and various combinations of isolation parameters, e.g. elastic stiffness, characteristic strength and post-yielding stiffness, representing common types of isolation devices are evaluated.
