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To make this assessment more precise and to incorporate variance information available from the sample replicates, we computed an ANOVA model and performed statistical testing.
We applied the three proposed tests that incorporate variance heterogeneity as well as the standard association test to the seven quantitative traits from ARIC as described above.
Cibere et al. found clinically acceptable reliability both before and after standardisation of ROM and muscle strength measurements but they did not incorporate variance components from the patients or random error and agreement parameters were not reported [ 17].
Generalised linear models incorporate variance overdispersion in the estimates of all standard errors to account for the clustering, since quality measures in newspaper stories about the same medical journal article could be correlated.
As primary summary effect estimates we calculated summary odds ratios and 95% confidence intervals according to the DerSimonian and Laird random effects model, which utilises weights that incorporate variance within and between studies.
However, the composite selection criterion goes beyond traditional P-values to incorporate variance between and within groups, as well as the variance of a single SNP's measurement on a single microarray.
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This solution is preferable to correcting distances between taxa before constructing the phylogeny, because the construction of the phylogeny should incorporate variances due to coverage and sequencing error that would be removed by tip corrections.
QTDT incorporates variance components methodology in the analysis of family data and includes exact estimation of p-values for analysis of small samples and non-normal data.
Nonetheless, our multiple-criteria composite for selection that incorporates variance across independent DNA pools is central to these newer analytic strategies.
We believe that this composite method, termed adjusted Chiang II, generates accurate estimates with an improved measure of uncertainty by incorporating variance for all age intervals.
For logistic and Poisson models, as examples, we incorporate the variance function prescribed by a superior model similar to a generalized linear mixed model to address overdispersion, and adopt a parameterized generalized family of link functions to deal with the problem of link misspecification.
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