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Approaches that can incorporate sequence data from large numbers of taxa and enable visualization of affinities across groups are desirable.
We propose here a hidden Markov model (HMM) to incorporate sequence motif information, TF-DNA interaction data and chromatin modification patterns to precisely identify cis-regulatory modules (CRMs).
To account for the complex features in the background signal, many methods incorporate sequence data from a control dataset generated from fixed chromatin [16] or DNA immunoprecipitated with a nonspecific antibody [18], [42].
Ssty2 does not incorporate sequence corresponding to exon 2 of Ssty1.
Nevertheless, there are a number of advantages for models that can incorporate sequence conservation.
Summary: Current strategies for SNP and INDEL discovery incorporate sequence alignments from multiple individuals to maximize sensitivity and specificity.
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Type II CRISPR systems incorporate sequences from invading DNA between CRISPR repeat sequences that are encoded as arrays within the bacterial host genome.
Zakeri et al. employed anther hybrid method to incorporate sequence-based descriptors, functional domain descriptors, and secondary structure information [ 25].
Although this is not uncommon, it leaves the possibility that other splicing events can incorporate sequences that are assumed to be intronic.
These results should remind educators that educational interventions that incorporate sequenced didactic and kinesthetic components are more effective in developing procedural competencies than didactic sessions alone.
The rescue-vector into which the gene sequence of interest is to be subcloned from the BAC is then manipulated by PCR to incorporate sequences homologous to the 5' and 3' ends of the desired gene sequence.
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