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However, low fidelity enzymes tend to efficiently incorporate incorrect nucleotides at the pause sites, and display the efficient primer extension products beyond the stop sites, whereas high fidelity enzymes exhibit little primer extension beyond the stop sites.
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The net effect of incorporating incorrect internal branch lengths by Bayesian integration is therefore to misinterpret convergent patterns that arise on long branches as due to common descent.
If a frameshift occurs during translation, the ribosome will continue to translate the mRNA in the wrong reading frame and to extend the protein by incorporating incorrect amino acids until a stop codon is reached in the new reading frame.
Pol η, pol κ, and pol ζ were significantly blocked one nucleotide prior to α-OH-PdG, incorporating incorrect nucleotides opposite this adduct with a much higher preference over the correct dC.
When the L561A and Y567A substitutions were combined in the same RB69pol variant, the resulting double mutant (dm) was 3 40-fold more likely to incorporate an incorrect dNTP than either of the single RB69pol mutants.
During DNA replication, DNA polymerase incorporates an incorrect base opposite to an aberrant base, causing a mutation.
When a pol incorporates an incorrect dNTP, it favors switching of the primer terminus from the pol to the exo subdomain, allowing for excision of the misincorporated base.
The Court felt it would be incorrect to incorporate customary international law rules into the meaning of law in Article 9(1) as this would cloak the common law with the constitutional status to nullify a statute, thus reversing the usual hierarchy of legal rules.
Efficient proofreading of incorrect nucleotides incorporated by the polymerase would seem to require efficient translocation of DNA between the exonuclease and polymerase active sites.
The other three approaches (Approaches 2a, 3a, and 3b) fail to incorporate sex effects, and give incorrect results when partitioning the variance components and calculating covariances between relatives.
His incorrect conclusions were incorporated into the 1964 edition of the definitive Köchel catalogue, which lists and dates all Mozart's works.
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