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Our research leverages a Conditional Value-at-Risk (CVaR) perspective to managing risks that can incorporate agent based simulation data in the decision-making process.
Once validated, a natural extension is to specifically incorporate agent memory and learning following Quek et al. (2009) and multi-player PD from evolutionary game theory to map the complex transaction networks that emerge over time.
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In addition to the need for local delivery, a critical barrier to progress in the field is the need to incorporate agents effective against biofilm.
Future work with this method could easily incorporate agents that modify the phenotype of NK cells that could favor homing and enhance multiple facets of effector functions [ 90– 92].
There is a strong rationale to support the idea that drug-eluting fibers can be designed to realize multiple design constraints in a single product for topical HIV prevention: fibers are able to deliver a wide range of agents, incorporate multiple agents via composites, and facilitate controlled release over relevant time frames for pericoital and sustained (coitally-independent) use.
In particular, we highlight MAS-ML, an MAS modelling language that performs a conservative extension of UML while incorporating agent-related concepts to represent proactive agents.
These include novel combinations incorporating agents such as irinotecan, topotecan, gemcitabine, vinorelbine and anthracyclines into docetaxel-containing regimens.
This may be due in part to the fact that breast cancer is an extremely complex and heterogeneous disease that operates multiple mechanisms of chemotherapeutic response and resistance which are not consistent across different subtypes, particularly in the case of combination regimens incorporating agents that act by multiple mechanisms.
The initial positive results of many clinical studies that explored the activity of alemtuzumab in relapsed and/or refractory CLL have provoked many oncologists to incorporate this agent into the treatment paradigm of this disease.
Even more recently, a few researchers have tried to incorporate contrast agents simultaneously with therapeutic agents using single nano-carrier for theranostic applications.
There are different ways to incorporate contrast agents into living cells, such as by, for example, the use of transfection agents (Frank et al., 2002) and the use of translocation peptides.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com