Such investigations have been especially important in regard to the manganyl (MnIVO or MnV(O) species, as there are no reports, to date, of any structurally characterized multinuclear model compounds that incorporate such a functionality.
The 2-bromo N- 3-azidopropyl -acetamide azide liN- 3-azidopropyl -acetamideis stable to hydrolysis iN- 3-azidopropyl -acetamidehas previously beeN- 3-azidopropyl -acetamidelazide of proteins to incorporate an azide functionalinkeror subsequent CuAAC reactions.
This binding may be exploited for the design of both CA as well as matrix metalloproteinase (MMP) inhibitors, since hydroxyurea is the simplest compound incorporating a hydroxamate functionality in its molecule.
From a practical point of view, incorporating a nitrogen functionality into this position of the glycolipid serves to increase substrate solubility (α-GalCer is very poorly soluble in most organic solvents and water), facilitating easier synthesis, purification, handling and biological administration.
Our experience in numerous clinical trials drove the design of QDOSE to incorporate all functionality within one stand-alone system.
These would seem an ideal continuation of previous efforts as they possess an affinity to lanthanides due to their O donors, but also incorporate a new N functionality which can take part in bonding, though to date there are significantly fewer 3d 4f and 4f compounds of this type than with 3d metals alone, so this is an ongoing area of research.
Novel recombinant MVP-only vaults have been created that not only retain native vault architecture but also incorporate a variety of functionalities internally and/or externally.
Rather than the next Oracle (who by the way was one of the study's underwriters) or even Salesforce.com emerging from this space, I'm betting that existing software-as-a-service companies incorporate the functionality themselves or you get a lot of built-in-house code.
Handspring's Treo line of "smartphones" — cell phones that incorporate the functionality of a PDA — are regarded by some as the best in their class, though they haven't been brisk sellers up to now.
While initially, this geometry has value as input data for the calculation of the energy efficiency of buildings, this can be modified to incorporate a rage of additional functionalities when data is shared online and is linked to the individual property addresses for a more accurate measurement.
That being said, the fact that Shorthand has struck deals with Nokia and Motorola to include its offering on their phones and could become a useful way to incorporate extra functionality into basic mobile phones.
