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First of all, the starting materials required for these methods are rather difficult to obtain, or they are fairly toxic and inconvenient to work with.
For example the starting materials required for these methods are rather difficult to obtain, or they are fairly toxic and inconvenient to work with and methods for direct fluorination and trifluoromethylation do not always allow the introduction of the CF3-group at the required position of a molecule.
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In that period an estimated 450,000 daily riders, mostly the poor and elderly, were left to find alternative transportation, frequently costly and inconvenient, to get to work.
"When you join a business, do you immediately start complaining that you have to work inconvenient hours?
But more than 20 mills survived in the town, staffed largely by migrants from India and Pakistan whose willingness to work inconvenient shifts had prolonged the industry's life and, in Seabrook's words, relieved the indigenous working class of some of the least-desirable employment.
Some challenges, however, raised by patients included the pill burden, inability to go to work, inconvenient timings, adverse reactions, and distance to the ART centre.
Perhaps he is extremely talented in a specialised area, or performs exceptionally well or agreed to work an inconvenient schedule.
The idea of destruction on such a massive scale can either be too difficult to contemplate or seem too out of our control to motivate action -- especially action inconvenient to us, like walking to work or bringing our own bags to the grocery store.
Flexibility, she says, should be seen not as a perk to work around the inconvenient fact that some people have children but as a way of enhancing the performance (and happiness) of both men and women, parents and the childless alike.
It can be inconvenient to replace batteries in devices that need to work over long periods of time.
A lawmaker pointed out that 3.14159 was impossibly inconvenient, and that 3.2 would be far easier to work with.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com