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Given the latter, we chose all-cause mortality as an end point that, although not including other "softer" end points such as nonfatal myocardial infarction and unstable angina, mitigates ascertainment bias and allows for assessment of an incontrovertible end point of vital clinical importance (23).
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Still, Dr. Daniel Levy, director of the Framingham study, said in an interview that there had been no single finding that changed medical thinking about how to diagnose high blood pressure, but rather a growing body of evidence that in the end seemed incontrovertible.
Kaine might begin by looking not at the end result — the incontrovertible fact that the four men confessed to a crime — but at the investigative process that led to those confessions.
"The outbreak appears to have ended with no incontrovertible evidence that any single treatment intervention, or combination of interventions, was unequivocally superior to the types of supportive medical care typically provided," the study authors wrote in a report about the trial, funded by the National Institute of Allergy and Infectious Diseases (NIAID).
History will render its own judgment on the ways that America's war was brought to an end, and those negatives, incontrovertible as they seem now, may in time be weighed against other factors still in the balance, including the price to be paid for pulling out in terms of the consequences for Iraq's tortured course to a post-Saddam Hussein political settlement.
But, in the end, the score is the incontrovertible star.
If Donald Trump had received 70% of the vote in last November's election, we would hear no end of boasting about his incontrovertible mandate from the American people.
Leader's volume ends up, though, making an incontrovertible case for the defence – man, not jerk – and it does so with the methods of a top-drawer American legal team: dizzying in detail, mitigating as a point of principle.
"In Memoriam" begins with the assertion that the Sept. 11 attack was "the most documented event in history"; by the end of the documentary, that seems incontrovertible.
For younger people too, Francis Fukuyama's triumphalism in his 1992 book The End of History – in which capitalism seemed incontrovertible, its overthrow impossible to imagine – exercises less of a choke-hold on their imaginations than it does on those of their elders.
But, in the end, as Rodgers and Hammerstein understood, the score is the incontrovertible star.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com