Exact(12)
We used clustering techniques to preprocess the input samples with the objective of indicating unrepresentative samples into isolated and inconsistent clusters, and used neural networks to construct the credit scoring model.
These clusters were termed inconsistent clusters and analysed in more detail.
In 64 out of the 81 inconsistent clusters all chlamydial proteins grouped together.
To check whether the inconsistent clusters resulted from a low cut-off value used for cluster formation, the proteins from each of the inconsistent clusters were aligned by ClustalW and subjected to phylogenetic analysis.
50 out of the 81 inconsistent clusters were not consistent with respect to results of signal peptide prediction, annotation, or both.
All Gene Ontology terms assigned to any of the genes in the set were tested for enrichment or depletion among the genes belonging only to inconsistent clusters.
Similar(48)
Their greater diversity is reinforced by inconsistent clustering across the genome.
For the analysis, 2 samples (GSM50775 and GSM50773) were excluded from the experiment because they have shown an inconsistent clustering: they represent control and treatment samples which clustered to each other as opposed to clustering with other control and treatment samples.
We believe this inconsistent clustering is a consequence of the low support at the root of the main clades (53 83% in all methods).
Incongruent tree topologies and inconsistent interserotype clustering show that the genetic relationship between different serotypes is not conserved throughout the genome.
On the other hand, recurrent mutation occurs one site at a time, so that it is unlikely to observe inconsistent sites clustering together in a long range.
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