Due to inconsistencies in expression levels of miRNAs in various sample mediums, miRNA biomarkers should be developed tissue-specific.
Inconsistencies in the level of specificity of the annotations of individual biomolecules can result in an apparently lower frequency in individual annotation terms, potentially leaving interesting patterns undetected.
However, inconsistencies in the level of protection afforded by the administration of antigen coupled to commercially available PLG nanoparticles indicated a need for particle modifications.
The heterogeneity in clinical outcomes across different diseases, discrepancies in time points for outcome measurements, and the inconsistency in the levels of outcome reporting, also limited the type of analyses and, therefore, the conclusions that could be drawn regarding the effectiveness and safety of some orphan drugs.
Their results were consistent with the original species descriptions based on morphological and isozyme characteristics, but revealed inconsistencies in the level of genetic divergence between genotypes, subspecies and species (e.g. pairwise divergence between genotypes of different P. vinckei subspecies was shown to be much higher than between genotypes of P. berghei and P. yoelii) [ 1, 14].
A number of experimental models of OA have been developed and used in the horse (Table I), but many have deficiencies with inconsistency in the level of disease between animals, as well as appropriateness to naturally occurring OA in the horse.
The inconsistencies in the expression levels of genes may have been because the data were obtained using different methods, from different sub-species, or from seeds at slightly different stages of germination.
Some inconsistencies between the levels of PrPBSE determined either by immunohistochemistry or by the rapid tests were found in brain areas with medium to low levels of PrPBSE.
Drawing on Mason's (1997) work, he (2000, pp. 427 8) hypothesizes that "very low fertility in advanced countries today is the outcome of a conflict or inconsistency between high levels of gender equity in individual-oriented social institutions and sustained gender inequity in family-oriented social institutions".
Therefore we can determine the accurate hierarchy of a GRN that we define as its hierarchical structure without having any inconsistencies in the level assignments.
