Due to inconsistencies in expression levels of miRNAs in various sample mediums, miRNA biomarkers should be developed tissue-specific.
Therefore we can determine the accurate hierarchy of a GRN that we define as its hierarchical structure without having any inconsistencies in the level assignments.
Inconsistencies in the level of specificity of the annotations of individual biomolecules can result in an apparently lower frequency in individual annotation terms, potentially leaving interesting patterns undetected.
However, inconsistencies in the level of protection afforded by the administration of antigen coupled to commercially available PLG nanoparticles indicated a need for particle modifications.
Their results were consistent with the original species descriptions based on morphological and isozyme characteristics, but revealed inconsistencies in the level of genetic divergence between genotypes, subspecies and species (e.g. pairwise divergence between genotypes of different P. vinckei subspecies was shown to be much higher than between genotypes of P. berghei and P. yoelii) [ 1, 14].
Low ratings were given to those substances with fewer studies available and/or some inconsistency in reported levels across studies (asbestos, 1,3-butadiene and nickel).
The exact reason for this is unclear; however, we speculate that the inconsistency in miRNA levels may be due to methodology, assay sensitivity, normalization procedures, and sample properties.
Therefore, we suspect that the inconsistency in GSH levels between TQ Green imaging and bulk lysate measurement in 3T3-L1 is due to an overestimation of the 3T3-L1 cell volume, and thus an underestimation of GSH concentration in the lysate.
The heterogeneity in clinical outcomes across different diseases, discrepancies in time points for outcome measurements, and the inconsistency in the levels of outcome reporting, also limited the type of analyses and, therefore, the conclusions that could be drawn regarding the effectiveness and safety of some orphan drugs.
Although many authors have demonstrated various anti-inflammatory mediators in Perna canaliculus, inconsistencies in therapeutic activity levels persist.
