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Inconsistent clinical trials using TLRs to boost immune systems against cancer is largely due to our incompletely understanding of TLRs' roles in CSCs.
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Despite their widespread use, the biological mechanisms underlying the efficacy of psychotropic drugs are still incompletely known; improved understanding of these is essential for development of novel more effective drugs and rational design of therapy.
An explanation for poorly understood phenomena in muscle contraction (Section 3) requires better understanding of the incompletely understood molecular mechanisms considered below.
Nevertheless, the expression of PD-1 and its ligands PD-L1 and PD-L2 during TB remains incompletely defined, thus hampering the understanding of how PD-L1/PD-1 may regulate the immune response to Mtb.
Standard animal behavior paradigms incompletely mimic nature and thus limit our understanding of behavior and brain function.
It found that the work had been incompletely done, and was based on less than a full understanding of the canyon's geology.
In conclusion, both the dynamics and the structure of the TGN are variable and incompletely defined, thereby presenting an additional layer of difficulty to our understanding of the biogenesis of the carriers that depart from this organelle.
Thus, our understanding of the high incidence of pneumonia in stroke patients is still incompletely.
However, our understanding of the relationships among meteorological parameters, air pollution, and health remains incompletely defined [ 15- 18].
Misconceptions are not inherently inaccurate, but rather are inappropriately or incompletely applied to a given biological context in a way that is not aligned with our current scientific understanding of the world (Leonard et al., 2014).
It is important to improve our understanding of the toxicity, environmental and human risks associated with the NDL-PCBs, since their toxicology is incompletely characterized and a human health risk assessment is required.
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