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Previous studies (e.g. refs [ 3, 4]) have mapped the duplication of the control region and translocation of tRNALEU to the internal branch leading to extant alethinophidians, but incomplete taxon sampling (especially the absence of Anilius) had left this proposition incompletely tested.
He continued his advocacy by mail, offering the following rebuttal to Holmes's accusation: "Opinions are at best provisional hypotheses, incompletely tested.
Meanwhile there is controversy over the validity of judging science by equating merit with publishing performance [12] [16], and the future direction of science is being influenced by hiring committees, funding agencies and officials using biased and incompletely tested bibliometric measures [9] [11].
If all puppies in the litter were not tested (ie the litter was incompletely tested), the reasons for this were noted.
The review did not include incompletely tested agents or regimens, such as bevazcizumab (representing the class of angiogenesis inhibitors), due to either inconsistent effects in stage IV or absence of data from adjuvant trials, or both.
The dogs included in the study were either from completely or incompletely tested litters of pups, usually tested when between six and eight weeks of age, or single breeding dogs from outside sources that were tested before breeding, having been untested as puppies.
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After accounting for clustering of outcomes within litters and kennels using a multilevel logistic model, the odds of deafness (any deaf ears rather than normal hearing) were similar in dogs tested as incompletely-tested litters relative to those tested as complete litters (odds ratio 1.2; 95% CI 0.5 to 2.8; P = 0.693).
However, there was some evidence that these proportions differed between dogs where incompletely-tested litters were tested compared to the testing of single dogs (P = 0.078), with a higher proportion of single dogs having normal hearing and lower proportions having unilateral deafness and bilateral deafness.
ALG13 did not react with Ub-PA, but it did react with haloalkyl probes, and A20 reacted very slowly and incompletely with all tested probes.
Associations between exposure variables and CHSD were assessed using only the 810 dogs tested as part of completely- or incompletely-tested litters (ie we excluded single dogs tested as replacement breeding stock from these analyses).
A total of 69% of Haemaphysalis spp. ticks tested harbored an incompletely described rickettsia.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com