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Potten hypothesised that it was an altruistic response in which the cells died, rather than expose the organism to the cancer risk of incompletely repaired genetic damage.
(80) A progression of G2 cells with incompletely repaired DNA breaks through the cell cycle could be responsible for the observed S-phase arrest and DSB during chronic exposures to Cr VI).
Cumulative DNA damage during aging is the result of errors in DNA replication occurring at low but finite rate or of incompletely repaired DNA damage (Yaar and Gilchrest, 2001).
The mechanism of potentiation appears to be similar to that seen with PARP inhibition, namely, persistent single-stranded DNA breaks incompletely repaired by BER being converted into DSB during replication, thereby leading to cell death.
Similar(56)
Does the detection of mutation reveal when it was modified and/or repaired, albeit incorrectly or incompletely?
Brutalization repaired.
The repaired complex produces a repaired DSB.
A new paradigm for persistent asthma is emerging of a damaged epithelium that repairs incompletely and leads to a chronic wound scenario with the secretion of a range of growth factors capable of driving structural changes linked to airway remodeling [ 127- 129].
During repair of DNA double strand breaks, or repair of other DNA damages, incompletely cleared sites of repair can cause epigenetic gene silencing.
However, the role of BM-MSCs on repairing skin appendages in renewal tissues is incompletely explored.
To repair".
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