This is a very pertinent point and it was, in fact, only on re-reading it from the 'non-terrestrial' perspective, that we realised how incompletely it was framed.
While its regulation is complex and incompletely understood, it is notable that, like human insulin, its expression is high when food levels are high and low when food levels are low.
The essential contribution of NRP-1 to vascular development and neovascularization is also well documented [ 11] and, although its mechanisms of action remain incompletely understood, it is thought to regulate cell-surface-receptor clustering and signalling in a ligand-dependent manner.
While the functions of ORMDL3 are incompletely understood, it is known to be involved in sphingolipid metabolism and de novo sphingolipid synthesis [6], suggesting altered sphingolipid metabolism as a contributing factor in asthma.
Although the mechanistic basis for the regulatory function of NKT cells is incompletely understood, it is mediated at least partly by the unique ability of NKT cells to produce Th1 and Th2 cytokines rapidly and in high concentrations [16], [17], [18], [19].
Although the exact origin and generation of ERG waves remain incompletely understood, it is well accepted that the negative a-wave originates primarily from photoreceptor cells and the positive b-wave derives from the electrical response between photoreceptor cells and neural cells in the inner retina such as bipolar and amacrine cells [29].
Although the etiology of IBS is incompletely understood, it is generally regarded as a multifactorial disorder involving the interplay of both host and environmental factors, including diet.
Although the pathogenesis of asthma is incompletely understood, it is clear that airway inflammation is a paramount feature of the condition.
Although the pathogenesis remains incompletely understood, it is characterised by severe, progressive synovitis with rapid destruction of the joint.
Although the precise pathogenesis of the disease is complex and remains incompletely understood, it is generally agreed that inflammation has a pivotal role.
