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Ample experimental evidence supported this paradigm; however, it appeared that it was somewhat reductive and could incompletely explain various situations of tolerance to foreign antigens or immune/inflammatory reactions to endogenous antigens.
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The Navajo occupied lands left by the Anasazi, whose departure is still incompletely explained.
Mutational and neoantigen load appears to incompletely explains immune responses in breast cancer.
Incompletely explained events, as in Figure 4G, had a single combination of SNP alleles (e.g. GG) co-occurring with multiple different gene model phenotypes.
Analogously, we observed that for many of the incompletely explained events, one event phenotype was much more common in the intermediate genomes, and the other version appeared only rarely (Figure 3C).
Testicular germ cell tumors (TGCT) exhibit striking familial aggregation that remains incompletely explained.
Allergic rhinitis is a common disease whose genetic basis is incompletely explained.
There was significant heterogeneity (P < 0.001), which was incompletely explained by subgroup analyses and meta-regressions.
Additional elements and pathways contribute to the perinuclear localization of budding yeast telomeres and centromeres, many being incompletely explained.
However, significant heterogeneity was identified in the COPD prevalence, and this heterogeneity was incompletely explained by subgroup analyses.
The advent of Next Generation sequencing and new approaches to disease modelling may allow the identification and validation of novel genetic variants in patients with previously incompletely explained or understood GRD.
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