Sentence examples for incompletely block from inspiring English sources

Allosteric mTOR inhibitors, such as rapamycin, incompletely block mTORC1 compared with mTOR kinase inhibitors (TORKi).

Our observations confirmed the findings of others [4] and showed that neutralization of TGFβ partially but incompletely blocked suppression.

Similarly, DNA fragmentation by palmitate was incompletely blocked by the caspase 9 inhibitor at 48 h (Fig. 6D).

A caspase 9-selective inhibitor blocked caspase 3 activation but incompletely blocked apoptosis in response to palmitate, suggesting an additional caspase 9-independent pathway.

However, HIF-1α ubiquitinylation is incompletely blocked by exogenous or hypoxia-derived hydrogen peroxide (Guzy et al. 2005), suggesting the involvement of additional mechanisms.

These properties are opposite to those of the S. mansoni P2X, which was more potently inhibited by suramin and incompletely blocked by PPADS [ 12].

Importantly, expression of PKI-mCherry significantly (albeit incompletely) blocked the inhibition of migration in response to Frsk and IBMX (Fig. 4E).

Inhibition of mGAT1 for a few minutes does not affect the release of GABA from SNc axons, indicating either that this pharmacological manipulation incompletely blocks GABA reuptake, or that it is too short to deplete presynaptic GABA levels.

Although GM6001 usually caused a complete abolition of cell invasion through collagen I matrices, a few cells occasionally traversed the membrane, which we speculate occurred as a result of rare pores being incompletely blocked due to irregularities in the transwell membrane itself (double holes) or the presence of air bubbles formed during matrix polymerisation.

Incubation of NK cells with caspase inhibitors blocked TiA incompletely, indicating that TiA is partly based on caspase-independent mechanisms.

This is because rapamycin blocks mTORC1 incompletely, and weak mTORC1 substrates would be the first or more acutely affected by reduced mTORC1 activity.