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They point to worrisome signs: the banning of an antipipeline protest, the temporary closure of an irreverent radio station, the execution of criminals after what critics believe to be incomplete trials.
The meta-analysis results obtained by using prognostic method, interval method, and traditional method for incomplete trials information are provided in Table 1.
The third column stands for the result obtained by the interval method (Int for short) and the last column stands for the result given by the traditional method on meta-analysis with incomplete trials information (Inc for short), i.e., removing trials with incomplete information.
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To present a structured account of ethical problems and possible solutions related to selective publication and incomplete trial registration.
The discontinuation rate was 55%% (n = 105): no benefit or inadequate benefit (n = 49), cost and lack of National Health Service coverage (n = 17), inconvenient (n = 15), migraine improved or resolved (n = 12), inadequate or incomplete trial (did not change dose when suggested; n = 7), side effects (n = 2) and none stated (n = 3).
That is, the prognostic method is more stable and precise than the traditional method for incomplete trial information.
When clinical trial results were only published in scientific journals, the decision whether to publish the results was completely left to the investigator, which led to incomplete trial reporting and publication bias [ 21].
This is because when some input data are imprecise, the prognostic method will get wrong predictions for missing SEMs, hence obtain worse meta-analysis results whilst the traditional method for incomplete trial information simply abandons trials with incomplete information, avoiding any wrong predictions and therefore may obtain better results.
Incomplete clinical trials using epidermal growth factor receptor (EGFR) antagonists have been performed on patients with salivary gland cancer.
This validation design mimics the prediction problem faced by breeders in incomplete field trials where lines are evaluated in some but not all target environments.
Two publications were excluded because of presentation-driven interim analyses of incomplete clinical trials, one of them reported within a review publication 26, 27 (NCT01143402, NCT01143402).
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