Exact(5)
To present a structured account of ethical problems and possible solutions related to selective publication and incomplete trial registration.
The discontinuation rate was 55%% (n = 105): no benefit or inadequate benefit (n = 49), cost and lack of National Health Service coverage (n = 17), inconvenient (n = 15), migraine improved or resolved (n = 12), inadequate or incomplete trial (did not change dose when suggested; n = 7), side effects (n = 2) and none stated (n = 3).
That is, the prognostic method is more stable and precise than the traditional method for incomplete trial information.
When clinical trial results were only published in scientific journals, the decision whether to publish the results was completely left to the investigator, which led to incomplete trial reporting and publication bias [ 21].
This is because when some input data are imprecise, the prognostic method will get wrong predictions for missing SEMs, hence obtain worse meta-analysis results whilst the traditional method for incomplete trial information simply abandons trials with incomplete information, avoiding any wrong predictions and therefore may obtain better results.
Similar(55)
They point to worrisome signs: the banning of an antipipeline protest, the temporary closure of an irreverent radio station, the execution of criminals after what critics believe to be incomplete trials.
The meta-analysis results obtained by using prognostic method, interval method, and traditional method for incomplete trials information are provided in Table 1.
The third column stands for the result obtained by the interval method (Int for short) and the last column stands for the result given by the traditional method on meta-analysis with incomplete trials information (Inc for short), i.e., removing trials with incomplete information.
This was a randomized, double-blind, phase IIb, incomplete crossover trial (ClinicalTrials.gov #NCT01040403; 1237.18) conducted between February 2010 and February 2011.
Not all cases were available for evaluation with a total of 22 cases (15.7%) missing due to tissue loss during staining or incomplete clinical trial data.
This was a double-blind incomplete crossover trial in which 233 patients with moderate or severe COPD were randomized to receive four out of eight free-dose combinations of olodaterol (5 or 10 µg) and tiotropium (1.25, 2.5, or 5 µg) or placebo for 4 weeks each.
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