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Strong net responses with low background spots, as seen in several cases in the ex vivo ELISpot results in this study, indicate an incomplete tolerance, and show that the ability to react to HBsAg specifically is still present in HBeAg negative HBV infected subjects.
Incomplete tolerance, some risk of autoimmunity and the ability to detect tumors are intrinsic properties of immune systems whose innate and adaptive components communicate probabilistically.
This constraint on central tolerance would still hold even if all self-Ags were expressed in the thymus and therefore, incomplete tolerance and residual self-reactivity are not faults but intrinsic properties of the vertebrate IS.
At the same time, however, the incomplete tolerance of Tev-mTALENs to variation in the DNA spacer between the TALE binding site and the cleavage motif that we observed highlights the need for additional study.
Development of antidonor Abs (antibodies) is associated with the occurrence of chronic rejection and late graft loss in clinical transplantation and suggests incomplete tolerance in the experimental setting (34).
Similar(55)
This is done in order to negate an "incomplete cross tolerance" among opioids.
An additional 13 mothers and 12 fathers had incomplete glucose tolerance test data.
The underlying rationales behind opioid rotation are incomplete cross tolerance and the possibility of improved pain control through achieving maximum dose titration of the opioid in the patients with intrinsically opioid-responsive pain [ 5].
When converting from one opiate to another, the new opiate should be given at 50%to67%7% of the calculated dose for all opiates, except fentanyl and methadone, to allow for incomplete cross-tolerance.
Both the MDSInit and RandInit approaches are shown to have comparable minimization performance in terms of error from the actual distances, while the MDSInit approach has a lower tolerance to incomplete pairwise distances.
Aside from incomplete understanding of immune tolerance, discrepancies arising from a continuum of 'autoimmune' reactions – ranging from normal physiological and inflammatory processes to uncontrolled disease – have destabilized the self/non-self dichotomy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com