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Incomplete resistance reduces the selection coefficient favoring resistant individuals over susceptible individuals on Bt crops.
The best long-term strategy for limiting damage caused by O. crenata is the development of resistant crops, but only moderate to low levels of incomplete resistance with a complex inheritance has been identified in crop legumes so far.
Furthermore, incomplete resistance could be enhanced by engineering desirable traits into novel GM crops.
The high level of cross-resistance and stability of incomplete resistance in the field population is of some concern.
Thus, the sustainability of GM crops that target haplodiploid or parthenogenetic pests will require careful consideration of the effects of reproductive mode, fitness costs, and incomplete resistance.
Two additional factors are needed to effectively delay or prevent the evolution of resistance in such pests, large recessive or smaller non-recessive fitness costs must reduce the fitness of resistance individuals in refuges (and ideally also on GM crops), and resistant individuals must have lower fitness on GM compared to non-GM crops (incomplete resistance).
Similar(22)
Moreover, an incomplete cross resistance with doxorubicin has been suggested.
Incomplete cross-resistance has also been demonstrated between sunitinib and bevacizumab.
Although seldom used front line, bendamustine shows incomplete cross-resistance with other alkylating agents, making its potential use in salvage therapy particularly attractive.
Therefore, a consequence of the unique, TP-mediated mechanism of action of capecitabine may be incomplete cross-resistance to conventional 5-FU in tumours overexpressing TP.
Despite experiencing dramatic clinical responses, patients who initially respond to gefitinib eventually develop progressive disease or incomplete cross-resistance to the currently available EGFR-TKIs like erlotinib [ 15, 16].
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