The increased risk of preterm birth after a short interpregnancy interval may be explained by an incomplete remodeling of the cervix.
These models show incomplete remodeling of maternal spiral arteries, fetal and placental growth restriction, hypertension, and proteinuria.
Male sub and infertility can be assessed at 7% of the male population trying to reproduce (Irvine, 1998), and has among others been associated with incomplete chromatin remodelling towards the protamine dominated state (de Mateo et al., 2011b; Ramos et al., 2008).
In such situations, the balance of matrix production and degradation tips in favor of production, which can be facilitated by overexpression of TIMPs or loss of MMP expression, resulting in incomplete matrix remodeling and irreversible fibrosis (Issa et al., 2004).
Pre-eclampsia with an early onset has been proposed to have a stronger association than late-onset pre-eclampsia with inadequate and incomplete spiral artery remodelling.
Our results support a stepwise mechanism for the replacement of H2A with Htz1 and demonstrate that a tight control of this mechanism is essential to regulate chromatin dynamics but also to prevent the deleterious consequences of an incomplete nucleosome remodelling.
In summary our results in yeast provide new insights into the mechanism of histone replacement and highlight the importance of a tight control of this process not only to assemble a proper chromatin structure but also to prevent the deleterious consequences of an incomplete nucleosome remodelling.
Failure of the release of cytokines from damaged muscle could account for the impairment of inflammatory cell recruitment at an early stage of regeneration with subsequent incomplete muscle remodelling, resulting in the persistence of inflammatory cells and necrotic fibres, and over time, the development of muscular dystrophy.
Malplacentation disorders are characterized by shallow interstitial invasion of fetal-derived trophoblast cells into maternal decidua and myometrium, and impaired endovascular trophoblast invasion resulting in incomplete maternal spiral artery remodelling.
In fact, our group has demonstrated that the altered progression of trophoblast invasion is correlated to incomplete spiral artery remodeling in rodents exposed to a life-long high-fat diet [ 7].
