Sentence examples similar to incomplete nonsense from inspiring English sources
In Coq9 R239X mice, the residual Coq9 mRNA observed in cerebrum and kidney from incomplete nonsense-mediated decay is translated into an aberrant COQ9 protein without the C-terminal 75 amino acid residues of the mature COQ9 protein.
Our study suggests that the presence of a COQ9-truncated protein because of an incomplete nonsense-mediated mRNA decay (NMD) induces instability of the CoQ mutiprotein complex and contributes in this way to the genetic and tissue-specific pathomechanisms.
The mouse reference genome has at least 21 distinct Mup genes (with open reading frames), and a further 21 Mup pseudogenes (with reading frames disrupted by a nonsense mutation or an incomplete gene duplication).
Nonsense (TAA, TAG and TGA) or incomplete codons (at the end of strings, generated by insertions or deletions) are not translated.
Another way to control genes is by nonsense-mediated decay, where incorrect or incomplete RNA molecules are destroyed before they can be used to make defective proteins.
However, as the premature termination occurs in exon 6, an internal exon, it would be expected to result in nonsense mediated decay, a process by which mRNAs encoding incomplete proteins are degraded during translation.
Alternatively, spliced variants in tumour cells are usually rapidly degraded through the so-called nonsense-mediated decay pathway, to prevent the synthesis of incomplete and potentially harmful proteins.
