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Fibrosis following injury leads to aberrant regeneration and incomplete functional recovery of skeletal muscle, but the lack of detailed knowledge about the cellular and molecular mechanisms involved hampers the design of effective treatments.
On the other hand, the tissues that are generated do not need to integrate in the body, with less risk of adverse effects in the event of incomplete functional, neuronal or humoral adaptation.
In addition, errors in the prediction can be caused by incorrect and incomplete functional annotations.
These findings were interpreted as evidence for incomplete functional redundancy at multiple levels in the genetic architecture [9].
While some of these changes favor axonal regeneration, other signals drastically dampen the protective response, resulting in either failed or incomplete functional recovery.
Remarkably, all these molecular interacting sites likely represent an incomplete functional map of CRYs.
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The pentose phosphate (PP) pathway in mycoplasmas is considered to be incomplete, but functional [34].
We found that approximately 85% of the clones in our library contain full-length inserts; although this means that some of the cloned fragments are incomplete, the functional characterization of partial cDNAs in the library still allows the retrieval of sequence data for further experiment design and for the isolation of the full-length cDNA of specific genes.
The structure of the catalytically inactive Mominus CODH indicates that an intracellular Mo-deficiency affects exclusively the active site of the enzyme as an incomplete non-functional molybdenum cofactor was synthesized.
Because the GOrilla enrichment relies on incomplete annotation of functional processes and can overlook functional connections even in well-annotated genes, we used the top enrichment as a focus for further manual curation, based on mining the PubMed literature database.
Tgfb2 contributes, with other factors of the TGF super-family such as BMP, Activin and Myostatin, to myogenesis [13] (Fig. 5) and may participate to the regeneration process that is impaired by aging, resulting in the incomplete structural and functional recovery after muscle injuries in elderly people [14].
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