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The researchers also found that short AGI was associated with incomplete descent of one or both testicles.
Cryptorchidism (CO) is the most frequent congenital disorder in male children (2-42-4% full-term male births) and is defined as incomplete descent of one (unilateral) or both (bilateral) testes and associated structures.
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In a preliminary analysis, the mean AGD in 13 infants with incomplete testicular descent at birth was shorter than in males with normal testis descent (17.5 mm vs. 19.9 mm) (Table 6).
We looked at the proportion of boys with incomplete testicular descent in these groups.
Cryptorchidism (incomplete testicular descent) is a common congenital disorder, but may also be acquired [ 1].
The boys with short AGI were also significantly more likely to have incomplete testicular descent (cryptorchidism).
Fourteen male infants had genital abnormalities at birth (incomplete testicular descent, 13; hypospadias, 2).
AGD was significantly correlated with penile volume (R = 0.27, p = 0.001) and the proportion of boys with incomplete testicular descent (R = 0.20, p = 0.02).
We also noted a similar trend in AGD measurements in infants with incomplete testicular descent at 3, 12, and 24 months of age.
"We know that incomplete testicular descent is a risk factor for poorer semen quality, lower sperm counts, [impaired fertility], and testicular cancer," says Swan.
The median concentrations of phthalate metabolites that are associated with short AGI and incomplete testicular descent are below those found in one-quarter of the female population of the United States, based on a nationwide sample.
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