Exact(28)
A single stimulation event from an extracellular cue may only result in incomplete depletion of the store (Berridge et al., 2000; Prakriya and Lewis, 2015).
The reason the relief was only partial was likely due to incomplete depletion of Beclin1 and existence of autophagy-independent immune evasion mechanisms, as exemplified by the deubiquitination of RIG-I, TRAF3, etc. by PLPs (Sun et al., 2012a).
Parameters such as the absence of Rheumatoid Factor or anti-CCP antibodies, multiple previous exposures to anti-TNF-α therapies, and high levels of circulating preplasma cell and subsequent incomplete depletion, have been recognized as predictors of treatment failure (Cohen et al., 2006; Thurlings et al., 2008; Vital et al., n.d).
Rituximab treatment also caused a significant, albeit incomplete, depletion of B cells within the SPL (Figure 2C) and LN (Figure 2D) of hCD20Tg mice.
Importantly, several published papers that report to have applied this intestinal microbiota depletion protocol describe incomplete depletion of the cultivable bacteria[21] [23].
Here the difference in the fat mass in females was not statistically significant as in the complete knockout (possibly due to the incomplete depletion of Fto, the genetic background introduced by the Nestin-Cre transgene, or a sampling issue of individual variance).
Similar(32)
These differences might reflect the potency of MLN4924 treatment compared to incomplete RBX1 depletion and/or could be influenced by prolonged RBX1 depletion over 72 hr compared to 1 hr exposure to MLN4924.
Our inability to demonstrate an effect of PC61 treatment on DC function could not be explained by incomplete Treg depletion, as the same results were observed using a RAG1−/− model in which Treg depletion was profound.
Alternatively, incomplete Emb depletion might sustain sufficient export capacity in cells exposed to RNAi against Emb.
We cannot rule out that the partial loss of chromatin-bound Cap-H2 is due to incomplete RNAi depletion of Mrg15.
Overall, our independent screening and proteomic approaches identified the Arp2/3 complex and mDia1 as major contributors to the actin cortex, though contributions from Fhod1 and Daam1 cannot be entirely excluded, notably due to the incomplete mRNA depletion achieved in our experiments.
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