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Our crystal structures of both DEAD-domains and helicase domains in isolation reveal that the RNA binding site on each domain is in a conformation that is incompetent to bind RNA substrate.
In the p-Nephrin and p-TIR titrations, ∼6% and ∼11% of the proteins, respectively, were found to be incompetent to bind Nck.
As ERBB2 is incompetent to bind NRG1, transplanting unmodified MSCs that lack ERBB4 cannot activate NRG1-ERBB signaling, and thus stultifies the existing NRG1 in the infarcted myocardium.
Cancer-associated mutants of PPP2R1B have been shown to be incompetent to bind the B and/or C subunits in vitro, resulting in PP2A inactivation.
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However, Hsp70 mutants that are folding-incompetent, but are able to bind and maintain the solubility of denatured proteins, were as effective as WT Hsp70 in decreasing oxidative stress and the rate of proton leak across the inner mitochondrial membrane in glucose-deprived astrocytes (Ouyang et al., 2006).
Part of it, surely, is the Dunning-Kruger effect: the truly incompetent are too incompetent to realize that they're incompetent.
Are these female PhDs too incompetent to find a solution?
Secular haunted houses are incompetent to address these dangers.
I understand, in a way, why these people are still at it; research shows that the truly incompetent often have high self-confidence, because they're too incompetent to realize that they're incompetent.
Mr. McKiever was twice declared incompetent to stand trial.
"We are incompetent to solve the times," Emerson once said.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com