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In spinal cord tissue from an ALS patient with a FUSR521H mutation, we observed that in motor neurons containing cytoplasmic inclusions there is a near absence of nuclear FUS (Fig. 6A).
For this, we tried to generate nuclear-inclusion-forming proteins by fusing nuclear localization sequences (NLS) to muNS-related proteins in order to see if they could reach the nucleus and generate inclusions there.
Besides typical inclusions, there were many inclusions with irregular borders and reduced intensity of IF signal.
Patients with FTD in IBMPFD associated with a VCP mutation are known to show lentiform intranuclear inclusions in the neurons of their neocortex [ 23- 25]; however, the present case showed no such inclusions there.
Sampling throughout the neuraxis demonstrated that the topographic distribution of FUS pathology was distinct between these few cases aFTLD-U and late-onset BIBD, suggesting that although they share a common molecular pathology (i.e. FUS positive inclusions), there is considerable heterogeneity amongst the sporadic FUS inclusion body diseases.
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For inclusion there had to be at least two studies.
Note that the slightly higher number of RR estimates in the current/ever analysis arises from inclusion there of more sex-specific results.
As for cultural inclusion, there is no conservative tradition to defend.
(If that were the standard of inclusion, there would be way fewer apps overall).
The benefits go beyond simply social inclusion; there is growing research to support the idea of the "diversity dividend".
For Emory students steeped in training about prejudice and inclusion, there is no need to know the intentions of the midnight chalker.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com